Health & Environmental Research Online (HERO)


Print Feedback Export to File
7469668 
Journal Article 
Efficient synthesis and biological evaluation of two modafinil analogues 
De Risi, C; Ferraro, L; Pollini, GP; Tanganelli, S; Valente, F; Veronese, AC 
2008 
Yes 
Bioorganic & Medicinal Chemistry
ISSN: 0968-0896
EISSN: 1464-3391 
16 
23 
9904-9910 
English 
Non classical bioisosters of modafinil featuring interesting biological profile have been easily produced through replacement of the sulfoxide function with a carbonyl group and modification of the carboxylic acid amide functionality. © 2008 Elsevier Ltd. All rights reserved. 
[3H]5-HT efflux; Bioisosters; Modafinil; Rat cerebral cortex slices; 3 oxo 4,4 diphenyl n (propan 2 yl) butanamide; 3 oxo 4,4 diphenylbutanamide; 5 (1 hydroxy 2,2 diphenylethylidene) 2,2 dimethyl 1,3 dioxane 4,6 dione; carbonyl derivative; carboxylic acid derivative; diphenylacetyl chloride; ethyl 3 oxox 4,4 diphenylbutanoate; modafinil; n o bis (tert butoxycarbonyl) n hydroxy 3 oxox 4,4 diphenylbutanamide; serotonin; sulfoxide; tert butyl (3 oxo 4,4 diphenylbutanoyl)carbamate; unclassified drug; animal experiment; animal tissue; article; biological activity; brain cortex; controlled study; drug synthesis; evoked response; male; nonhuman; rat; serotonin uptake; Sprague Dawley rat; Animals; Benzhydryl Compounds; Central Nervous System Stimulants; Data Interpretation, Statistical; Male; Rats; Rats, Sprague-Dawley; Serotonin; Stereoisomerism; Rattus 
Other
• Harmful Algal Blooms- Health Effects
     April 2021 Literature Search
          Scopus