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7696153 
Journal Article 
Synthesis of hydroxy-alpha-sanshool 
Zhou, J; Xiao, Yan; Chen, T; Gao, J; Huang, W; Li, Z; , 
2021 
1 
Journal of Chemical Research
ISSN: 1747-5198
EISSN: 2047-6507 
SAGE PUBLICATIONS LTD 
LONDON 
45 
3-4 
310-314 
English 
WOS:000649144500016 
Hydroxy-alpha-sanshool was synthesized in a 13% overall yield through eight steps, which included two Wittig reactions that were used to form the carbon skeleton with ethyl 2-oxoacetate and 2E,4E-hexadienal being reacted with the appropriate ylides. Impurities in the processes could easily be separated. Ethyl 6-hydroxy-2Z-hexenoate was converted to its E-isomer with catalysis by I-2 and 2E,6Z,8E,10E-dodecatetraenoic acid was crystallized from a solution in 1% ethyl acetate in n-hexane. 
Hydroxy-α-sanshool; synthesis; Wittig reaction