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HERO ID
784776
Reference Type
Journal Article
Title
Evaluation of the interaction of coumarins with biomembrane models studied by differential scanning calorimetry and Langmuir-Blodgett techniques
Author(s)
Sarpietro, MG; Giuffrida, MC; Ottimo, S; Micieli, D; Castelli, F
Year
2011
Is Peer Reviewed?
Yes
Journal
Journal of Natural Products
ISSN:
0163-3864
EISSN:
1520-6025
Volume
74
Issue
4
Page Numbers
790-795
Language
English
PMID
21417386
DOI
10.1021/np100850u
Abstract
Three coumarins, scopoletin (1), esculetin (2), and esculin (3), were investigated by differential scanning calorimetry and Langmuir-Blodgett techniques to gain information about the interaction of these compounds with cellular membranes. Phospholipids assembled as multilamellar vesicles or monolayers (at the air-water interface) were used as biomembrane models. Differential scanning calorimetry was employed to study the interaction of these coumarins with multilamellar vesicles and to evaluate their absorption by multilamellar vesicles. These experiments indicated that 1-3 interact in this manner to different extents. The Langmuir-Blodgett technique was used to study the effect of these coumarins on the organization of phospholipids assembled as a monolayer. The data obtained were in agreement with those obtained in the calorimetric experiments.
Tag
IRIS
•
Dioxin (2012 Project Page for Final Report)
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