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HERO ID
786120
Reference Type
Journal Article
Title
Vanadium pentoxide induces activation and death of endothelial cells
Author(s)
Montiel-Dávalos, A; Gonzalez-Villava, A; Rodriguez-Lara, V; Montaño, LF; Fortoul, TI; López-Marure, R
Year
2012
Is Peer Reviewed?
Yes
Journal
Journal of Applied Toxicology
ISSN:
0260-437X
EISSN:
1099-1263
Volume
32
Issue
1
Page Numbers
26-33
Language
English
PMID
21721017
DOI
10.1002/jat.1695
Web of Science Id
WOS:000298014100004
Abstract
Vanadium is a transition metal released into the atmosphere, as air-suspended particles, as a result of the combustion of fossil fuels and some metallurgic industry activities. Air-suspended particle pollution causes inflammation-related processes such as thrombosis and other cardiovascular events. Our aim was to evaluate the effect of vanadium pentoxide (V(2) O(5) ) on endothelial cells since they are key participants in the pathogenesis of several cardiovascular and inflammatory diseases. Cell adhesion, the expression of adhesion molecules and oxidative stress, as well as proliferation, morphology and cell death of human umbilical vein endothelial cells (HUVECs) exposed to V(2) O(5) , were evaluated. Vanadium pentoxide at a 3.12 µg cm(-2) concentration induced an enhanced adhesion of the U937 macrophage cell line to HUVECs, owing to an increased expression of late adhesion molecules. HUVECs exposed to V(2) O(5) showed an increase in ROS and nitric oxide production, and a diminished proliferation. These changes in vanadium-treated HUVECs were accompanied by severe morphological changes and apoptotic cell death. Vanadium pentoxide induced serious endothelial cell damage, probably related to the increased cardiovascular morbidity and mortality observed in individuals living in highly air-polluted areas. Copyright © 2011 John Wiley & Sons, Ltd.
Keywords
endothelial cells; vanadium pentoxide; inflammation; oxidative stress; apoptosis
Tags
•
Vanadium Compounds - Problem Formulation
Items Screened
Literature Search: Jan 2010 - Mar 2019
PubMed
WoS
Combined data set
Dataset for title/abstract screening
Supplemental (TIAB)
Supplemental material
Mechanistic
From 2011 V2O5 IRIS assessment
•
Vanadium Inhalation
Literature Search: Jan 2010 – Mar 2019
PubMed
WoS
Combined Dataset
Dataset for title/abstract screening
Supplemental (TIAB)
Supplemental material
Mechanistic (nongenotoxic)
Manual review of existing IRIS and PPRTV assessments
From 2011/2014 V2O5 IRIS assessment
•
Vanadium Pentoxide (Draft, 2011)
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