Jump to main content
US EPA
United States Environmental Protection Agency
Search
Search
Main menu
Environmental Topics
Laws & Regulations
About EPA
Health & Environmental Research Online (HERO)
Contact Us
Print
Feedback
Export to File
Search:
This record has one attached file:
Add More Files
Attach File(s):
Display Name for File*:
Save
Citation
Tags
HERO ID
786616
Reference Type
Journal Article
Title
Lead hepatotoxicology: A study in an animal model
Author(s)
Sá, I; da Costa, MJP; Cunha, EM
Year
2012
Is Peer Reviewed?
1
Journal
Toxicology and Industrial Health
ISSN:
0748-2337
EISSN:
1477-0393
Publisher
SAGE PUBLICATIONS INC
Location
THOUSAND OAKS
Volume
28
Issue
2
Page Numbers
108-113
Language
English
PMID
21665903
DOI
10.1177/0748233711407240
Web of Science Id
WOS:000300222800002
Abstract
The increasing use of lead (Pb) for industrial purposes has resulted in the significant increase in environmental contamination of our planet especially in concern to water and food. In this study using the electron scanning microscopy (SEM), the authors showed the effects of this metal as a result of a chronic and cumulative process. As a primary method of detection of Pb in situ, SEM was chosen, coupled with a detection system Noran Voyager of basic microanalysis X-ray (SEM-XRM), with detection system energy dispersive spectrometry. Mice BALB/c was used as a study model. An animal model of inflammation was used, that consisted in the formation of a subcutaneous pocket of air. It was observed that 75% of Pb stock was captured by the liver, the main target organ in the capture of the metal, the kidney was the second organ to capture the Pb stock and the third was the spleen. It was verified that a low deposition of Pb was found in the lungs and the brain. The main results of this study showed how Pb is captured by different organs. We also demonstrated the vulnerability to inflammation of this metal.
Keywords
Lead; liver; synergistic effect; SEM-XRM; inflammation
Tags
IRIS
•
Methylmercury
ADME Search: Jan 1990 - Nov 2018
Results with mercury
WoS
NAAQS
•
ISA-Lead (2013 Final Project Page)
Considered
Cited
2nd Draft
3rd Draft
Final
Health Effects
Home
Learn about HERO
Using HERO
Search HERO
Projects in HERO
Risk Assessment
Transparency & Integrity