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Citation
Tags
HERO ID
787814
Reference Type
Journal Article
Subtype
Review
Title
Insights from epidemiology into dichloromethane and cancer risk
Author(s)
Cooper, GS; Scott, CS; Bale, AS
Year
2011
Is Peer Reviewed?
Yes
Journal
International Journal of Environmental Research and Public Health
ISSN:
1661-7827
EISSN:
1660-4601
Volume
8
Issue
8
Page Numbers
3380-3398
Language
English
PMID
21909313
DOI
10.3390/ijerph8083380
Web of Science Id
WOS:000294248600022
Abstract
Dichloromethane (methylene chloride) is a widely used chlorinated solvent. We review the available epidemiology studies (five cohort studies, 13 case-control studies, including seven of hematopoietic cancers), focusing on specific cancer sites. There was little indication of an increased risk of lung cancer in the cohort studies (standardized mortality ratios ranging from 0.46 to 1.21). These cohorts are relatively small, and variable effects (e.g., point estimates ranging from 0.5 to 2.0) were seen for the rarer forms of cancers such as brain cancer and specific hematopoietic cancers. Three large population-based case-control studies of incident non-Hodgkin lymphoma in Europe and the United States observed odds ratios between 1.5 and 2.2 with dichloromethane exposure (ever exposed or highest category of exposure), with higher risk seen in specific subsets of disease. More limited indications of associations with brain cancer, breast cancer, and liver and biliary cancer were also seen in this collection of studies. Existing cohort studies, given their size and uneven exposure information, are unlikely to resolve questions of cancer risks and dichloromethane exposure. More promising approaches are population-based case-control studies of incident disease, and the combination of data from such studies, with robust exposure assessments that include detailed occupational information and exposure assignment based on industry-wide surveys or direct exposure measurements.
Tags
IRIS
•
DCM (Dichloromethane) (Final, 2011)
OPPT REs
•
OPPT_Methylene Chloride_C. Engineering
Total – title/abstract screening
Off topic
•
OPPT_Methylene Chloride_D. Exposure
Total – title/abstract screening
On topic
Peer review
Secondary source/Review
•
OPPT_Methylene Chloride_E. Fate
Total – title/abstract screening
Off topic
•
OPPT_Methylene Chloride_F. Human Health
Total – title/abstract screening
On topic
Peer review
Secondary source/ Review
Cited in IRIS document or IRIS HERO page
Other
•
Mouse Lung Tumor Workshop 2014
Session 3 – Biological Mechanisms
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