Renoprotective potential of Macrothelypteris torresiana via ameliorating oxidative stress and proinflammatory cytokines | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

834212

Reference Type

Journal Article

Title

Renoprotective potential of Macrothelypteris torresiana via ameliorating oxidative stress and proinflammatory cytokines

Author(s)

Chen, J; Lei, Y; Wu, G; Zhang, Y; Fu, W; Xiong, C; Ruan, J

Year

2012

Is Peer Reviewed?

Yes

Journal

Journal of Ethnopharmacology
ISSN: 0378-8741

Volume

139

Issue

Page Numbers

207-213

Language

English

PMID

22101083

DOI

10.1016/j.jep.2011.11.002

Web of Science Id

WOS:000299976900028

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE: Macrothelypteris torresiana is traditionally used in Chinese folk medicine for the treatment of edema for patients suffering from kidney/bladder problems due to its satisfactory therapeutic effectiveness. AIM OF THE STUDY: The aim of this study was to investigate the renoprotective nature of the total polyphenols fraction from Macrothelypteris torresiana (PMT). MATERIALS AND METHODS: The biochemical criterions of plasma and kidney tissues were evaluated to study the effects of PMT on puromycin aminonucleoside-induced chronic nephrotic syndrome (NS) in hyperlipidemic mice. RESULTS: In this study, the NS and hyperlipidemia were ameliorated after 9 weeks administration of PMT. Besides, PMT was able to modulate the level of renal oxidative stress and vascular endothelial growth factor-nitric oxide (VEGF-NO) pathway. CONCLUSIONS: It represented a potential resource of PMT for the treatment of NS involved in metabolic syndrome.

Keywords

Macrothelypteris torresiana; Nephrotic syndrome; Oxidative stress; Vascular endothelial growth factor; Nitric oxide