US EPA

8347541 

Journal Article 

1-(subsituted)-4, 4, 6-trimethyl-3, 4-dihydropyrimidine-2(1H)-thione: Green synthesis, antibacterial activity and DNA photocleavage activity 

Sharma, A; Khare, R; Kumar, V; Gupta, GK; Beniwal, V 

2014 

1 

International Journal of Pharmacy and Pharmaceutical Sciences
ISSN: 2656-0097
EISSN: 0975-1491 

6 

3 

171-175 

English 

Objective: 1-(subsituted)-4,4,6-trimethyl-3,4-dihydropyrimidine-2(1H)-thione: Green synthesis, antibacterial activity and DNA photocleavage activity. Methods: In the present study, 1-(subsituted)-4,4,6-trimethyl-3,4-dihydropyrimidine-2(1H)-thione has been achieved under mild reaction conditions by employing microwave assisted and grind stone method. All the synthesized compounds were evaluated for their DNA nicking activity. Some of them were selected as to evaluate their antibacterial effect against gram- positive (Enterococcus) and gram-negative (Escherichia coli, Klebsiella pneumoniae and Pseudomonas aeruginosa) bacteria. The outcome of the study indicating that compounds containing flour, methoxy and chloro substituent were found to exhibit complete DNA cleavage at 40 μg/μl concentration. Results: The reported compounds synthesized through greener methods such as grindstone and microwave assisted synthesis. Conclusion: Some of the compounds have exhibited promising antibacterial and DNA Photoclevage activity. 

2-thiopyrimidine; Antibacterial activity; DNA cleavage activity; Grindstone method; Microwave assisted synthesis