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Citation
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HERO ID
8592320
Reference Type
Journal Article
Title
Training partially reverses skeletal muscle metabolic abnormalities during exercise in heart failure
Author(s)
Stratton, JR; Dunn, JF; Adamopoulos, S; Kemp, GJ; Coats, AJS; Rajagopalan, B
Year
1994
Is Peer Reviewed?
Yes
Journal
Journal of Applied Physiology (1985)
ISSN:
8750-7587
EISSN:
1522-1601
Volume
76
Issue
4
Page Numbers
1575-1582
Language
English
DOI
10.1152/jappl.1994.76.4.1575
Abstract
Using 31P-magnetic resonance spectroscopy during and after exercise, we studied whether forearm metabolic responses to exercise were improved by 1 mo of training in 10 males with heart failure. In the control (untrained) arm, there were no changes in any of the measured variables. In the trained arm, maximal voluntary contraction increased 6% (P = 0.05). During incremental exercise, duration increased 19% (P < 0.05) and submaximal responses improved for pH (6.78 ± 0.13 pretraining vs. 6.85 ± 0.17 posttraining; P < 0.01) and PCr/(PCr + P(i)) (where PCr is phosphocreatine; 0.48 ± 0.09 pretraining vs. 0.52 ± 0.07 posttraining; P < 0.01). The PCr resynthesis rate increased by 48% (P < 0.01), and estimated effective maximal rate of mitochondrial ATP synthesis increased by 37% (P < 0.05). Endurance exercise duration increased by 67% (P < 0.01), and submaximal levels of PCr/(PCr + P(i)) (P < 0.05) and pH (P = 0.07) improved. The PCr resynthesis rate (P < 0.01) and the effective maximal rate of mitochondrial ATP synthesis (P < 0.05) also improved. These findings document that impaired oxidative capacity of skeletal muscle can be improved by local muscle training in heart failure, which is compatible with the hypothesis that a part of the abnormality present in heart failure may be due to inactivity.
Keywords
congestive heart failure; exercise training; maximal rate of mitochondrial adenosine 5'-triphosphate synthesis; phosphocreatine resynthesis; phosphorus-31 magnetic resonance spectroscopy; skeletal muscle metabolism
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