US EPA

86513 

Journal Article 

An algorithm for nasal pungency thresholds in man 

Abraham, MH; Kumarsingh, R; Cometto-Muniz, JE; Cain, WS 

1998 

Yes 

Archives of Toxicology
ISSN: 0340-5761
EISSN: 1432-0738 

BIOSIS/98/17569 

72 

4 

227-232 

English 

#Nasal pungency thresholds (NPT) in man have been determined by Cometto-Muniz and Cain for 44 varied compounds, including esters, aldehydes, ketones, alcohols, carboxylic acids, aromatic hydrocarbons and pyridine. With the exclusion of acetic acid, 43 of these NPT values are well correlated through the general linear free energy equation of Abraham, leading to the algorithm, log(1/NPT) = -8.519 + 2.154 pi(2)H + 3.522 sigma alpha(2)H + 1.397 sigma beta(2)H + 0.860 logL16. N = 43, r2 = 0.955, SD = 0.27, F = 201 (i) where the independent variables are solute descriptors: pi(2)H is the dipolarity/polarizability, sigma alpha(2)H and sigma beta(2)H are the overall or effective hydrogen-bond acidity and basicity, and L16 is the solute Ostwald solubility coefficient on hexadecane at 25 degrees C. Surprisingly, the aliphatic aldehydes and carboxylic acids fit the correlation and with respect to nasal pungency thresholds in man for brief (1-3 s) presentations must be regarded as 'nonreactive' compounds. It is suggested mere transport of the compound from the air stream to the receptor area largely determines the potency to produce pungency. Various chemical properties of the receptor area are deduced from the coefficients in Eq. i. 

Biochemical Studies-General; Sense Organs; Toxicology-General; Hominidae