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8716816 
Journal Article 
Total synthesis of (+)-epiepoformin and (-)-phyllostine 
Okamura, H; Shimizu, H; Yamashita, N; Iwagawa, T; Nakatani, M 
2003 
1 
Tetrahedron
ISSN: 0040-4020 
59 
51 
10159-10164 
English 
An efficient asymmetric total synthesis of naturally occurring cyclohexeneoxides, (+)-epiepoformin and (-)-phyllostine has been achieved using the chiral building block available from the base-catalyzed Diels-Alder reaction of 3-hydroxy-2-pyrone. Since (-)-theobroxide was derived from the same precursor of (+)-epiepoformin, the formal total synthesis of (-)-theobroxide has also been achieved. 2003 Elsevier Ltd. All rights reserved. 
Diels-Alder reaction; Epiepoformin; Phyllostine; Theobroxide; Total synthesis