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HERO ID
876015
Reference Type
Journal Article
Title
Ozonated autohemotherapy: protection of kidneys from ischemia in rats subjected to unilateral nephrectomy
Author(s)
Foglieni, C; Fulgenzi, A; Belloni, D; Sciorati, C; Ferrero, E; Ferrero, ME
Year
2011
Is Peer Reviewed?
Yes
Journal
BMC Nephrology
ISSN:
1471-2369
EISSN:
14712369
Volume
12
Page Numbers
61
Language
English
PMID
22081953
DOI
10.1186/1471-2369-12-61
Web of Science Id
WOS:000304369200001
Abstract
ABSTRACT: BACKGROUND: Ozonated autohemotherapy (OA) has been previously successfully used in the treatment of patients affected by peripheral occlusive arterial disease. OA consists of an intrafemoral reinfusion of autologous blood previously exposed to a mixture of oxygen/ozone (O2/O3). This study analyzes the effects of OA in protecting rat kidney from ischemia and ischemia/reperfusion damage. METHODS: We performed OA 30 min before the induction of 60 min renal ischemia or at the induction of 60 min postischemic reperfusion in rats subjected to unilateral nephrectomy. In addition, to evidence the possible protection induced by O2/O3 on endothelial functions, the present study analyzes the in vitro effects of O2/O3 on oxygen consumption by human umbilical vein endothelial cells (HUVEC). RESULTS: 1) OA preserves rat kidney functions and architecture, as demonstrated by the improved levels of serum creatinine and blood urea nitrogen and by histology; 2) such protection does not correlate with the increase of plasmatic nitric oxide, but is compatible with a focal renal increase of renal betaNADPH-diaphorase; 3) treatment of HUVEC with O2/O3 significantly increases both the rate of oxygen consumption and the mitochondrial activity assessed by confocal microscopy. CONCLUSION: The preservation of the mitochondrial activity of endothelium could in vivo limit the endothelial dysfunction provoked by the Isc or Isc/R processes.
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NAAQS
•
ISA-Ozone (2020 Final Project Page)
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