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HERO ID
90492
Reference Type
Journal Article
Title
Differences in airway reactivity in normal and allergic sheep after exposure to sulfur dioxide
Author(s)
Abraham, WM; Oliver, W, Jr; Welker, MJ; King, MM; Wanner, A; Sackner, MA
Year
1981
Is Peer Reviewed?
Yes
Journal
Journal of Applied Physiology (1985)
ISSN:
8750-7587
EISSN:
1522-1601
Volume
51
Issue
6
Page Numbers
1651-1656
Language
English
PMID
7319895
Web of Science Id
WOS:A1981MW82200043
Abstract
The effect of breathing 5 ppm sulfur dioxide (SOZ) on airway reactivity was studied in both normal and allergic conscious sheepreactivity was studied in both normal and allergic conscious sheep. Allergic sheep were defined as animals in which inhalation of Ascaris suum extract resulted in bronchospasm as evidenced by an increase in mean pulmonary flow resistance (RL), hyperinflation, and a fall in dynamic compliance. Airway reactivity was assessed by measuring the increase of RL after 18 breaths of 0.25% carbachol (c), from an initial RL value obtained after 18 breaths of buffered saline (s) [RL(c-s)]. RL and RL(c-S) were determined prior to, immediately after, and 24 h after exposure to 5 ppm SO2 for 4 h. In both groups RL remained unchanged after SO2 exposure. Prior to exposure, RL(c.s) was not significantly different in seven normal (0.3 +/- 0.1) and seven allergic sheep [0.4 +/- 0.2 (SD) cmH20 l(-1) s], and there was no significant change in RL (c.s) immediately after SO2 exposure in either group. Twenty-four h later, RL(c.s) RL(c-s) increased to 0.7 +/- 0.8 (P < 0.2) in normal and to 1.8 +/- 0.9 cmH2O l(-1) s (P < 0.01) in allergic sheep. Because the increase in RL(c.S) after 24 h was greater (P < 0.01) in allergic than in normal sheep, we conclude that SO2 exposure increased airway reactivity more in the former than in the latter.
Tags
NAAQS
•
ISA-SOx
Considered
Chapter Review
Health Effects
Cited in First ERD Nov2015
Cited Second ERD Dec2016
Cited in Final ISA Dec2017
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