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94838 
Journal Article 
Some hepatotoxic actions of hexachloroethane and its metabolites in sheep 
Fowler, JSL 
1969 
Yes 
British Journal of Pharmacology
ISSN: 0007-1188
EISSN: 1476-5381 
35 
3 
530-542 
English 
5809742 
1. Pentachloroethane and tetrachloroethylene were major metabolites of hexachloroethane in sheep.2. Concentrations of hexachloroethane, pentachloroethane and tetrachloroethylene were determined by gas-liquid chromatography in blood, bile, faeces, urine and tissues after oral administration of hexachloroethane emulsions to sheep.3. Increased blood concentrations of sorbitol dehydrogenase, glutamate dehydrogenase, and ornithine carbamoyl transferase were found to follow oral administration of hexachloroethane or pentachloroethane.4. The rate of bromsulphthalein transfer from liver cells to bile was found to decrease after oral administration of hexachloroethane.