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HERO ID
992263
Reference Type
Journal Article
Title
Hepatic encephalopathy and orotic aciduria associated with hepatocellular carcinoma in a noncirrhotic liver
Author(s)
Jeffers, LJ; Dubow, RA; Zieve, L; Reddy, KR; Livingstone, AS; Neimark, S; Viamonte, M; Schiff, ER
Year
1988
Is Peer Reviewed?
Yes
Journal
Hepatology
ISSN:
0270-9139
EISSN:
1527-3350
Volume
8
Issue
1
Page Numbers
78-81
Language
English
PMID
2828214
DOI
10.1002/hep.1840080116
Abstract
A 40-yr-old man presented with encephalopathy and was found to have hepatocellular carcinoma without cirrhosis. A large vascular hepatic mass was defined by CT scan and angiography; laparoscopy with biopsy confirmed the absence of chronic liver disease. A definitive tissue diagnosis of hepatocellular carcinoma was made at laparotomy; the tumor was unresectable. Peripheral arterial and selective portal and hepatic venous ammonia levels were high, and this finding suggested that the encephalopathy was nitrogenous and hepatic in origin. The proposed mechanisms of the encephalopathy are generation of ammonia from tumor breakdown and por-tosystemic shunting, a result of partial tumor occlusion of the hepatic veins. An unusually high urinary excretion of orotic acid was found similar to that seen in hereditary orotic aciduria.
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IRIS
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Ammonia
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Physical-Chemical/Mechanistic/Toxicokinetics Studies
Toxicokinetics
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