Jump to main content
US EPA
United States Environmental Protection Agency
Search
Search
Main menu
Environmental Topics
Laws & Regulations
About EPA
Health & Environmental Research Online (HERO)
Contact Us
Print
Feedback
Export to File
Search:
This record has one attached file:
Add More Files
Attach File(s):
Display Name for File*:
Save
Citation
Tags
HERO ID
999990
Reference Type
Journal Article
Title
Screening Multicomponent Reactions for X-Linked Inhibitor of Apoptosis-Baculoviral Inhibitor of Apoptosis Protein Repeats Domain Binder
Author(s)
Monfardini, I; Huang, JW; Beck, B; Cellitti, JF; Pellecchia, M; Dömling, A
Year
2011
Is Peer Reviewed?
Yes
Journal
Journal of Medicinal Chemistry
ISSN:
0022-2623
EISSN:
1520-4804
Publisher
AMER CHEMICAL SOC
Location
WASHINGTON
Page Numbers
890-900
Language
English
PMID
21241056
DOI
10.1021/jm101341m
Web of Science Id
WOS:000286798100017
Abstract
We report a second example of a general reaction screening approach to discover low molecular weight inhibitors of protein protein interactions. On the basis of the known pharmacophore model of SMAC mimetics, we predicted several inhibitors based on four different multicomponent reactions. The predicted inhibitors were subsequently synthesized, tested, and found to bind to the antiapoptotic protein X-linked inhibitor of apoptosis protein (XIAP) and showed cellular activity. Also the compounds are currently not highly potent. They could form a starting point for future medicinal chemistry optimization.
Tags
IRIS
•
Ammonia
Literature Search – March 2012 (private)
Literature Search Results
Home
Learn about HERO
Using HERO
Search HERO
Projects in HERO
Risk Assessment
Transparency & Integrity