Diisobutyl Phthalate (DIBP) Final

Project ID

2320

Category

IRIS

Added on

March 10, 2014, 11:43 a.m.

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PubMed
DOI WoS
Journal Article

A toxicological investigation of some acute, short-term, and chronic effects of administering di-2-ethylhexyl phthalate (DEHP) and other phthalate esters

Lawrence WH et al. 1975

Abstract  Twelve phthalic acid esters, including those commonly used as plasticizers for biomedical devices, were subjected to various biological tests for acute, short-term, and chronic toxicity. Certain aspects of subtle toxicity were investigated as well as overt toxic manifestations. The acute ip LD50 for these compounds in mice ranged from 3.22 to more than 100 g/kg. A comparison of acute LD50 to chronic LD50 reveals that most of these phthalates are 2–4 times more toxic chronically. However, the chronic toxicity of di-n-octyl phthalate was 21.74 times greater than its acute toxicity, while for di-2-ethylhexyl phthalate the chronic toxicity was 27.99 times greater. Most of these compounds produced a prolongation of pentobarbital sleeping time in mice pretreated with a phthalate ester.

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