Propylene glycol ethers (88917-22-0 & 55934-93-5)

Project ID

2818

Category

OPPT

Added on

July 2, 2019, 11:49 a.m.

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132 items found. Displaying 25 items on page 4 of 6.

Technical Report

1-butoxypropan-2-ol: Acute toxicity: Oral: 001 Key | experimental result

European Chemicals Agency 1987

Abstract  Three groups of Wistar rats (5/sex/dose level) received single oral doses of 1800, 2400, or 3200 mg/kg propylene glycol n-butyl ether (PnB), administered undiluted using a stainless steel stomach cannula attached to a syringe. No rats died from a dose of 1800 mg/kg PnB. One female died after a dose of 2400 mg/kg. Four females and one male died at 3200 mg/kg. The calculated oral LD50 for males alone was 5500 mg/kg (no 95% confidence limits), for females alone was 2700 mg/kg (95% CL: 2400 - 3600 mg/kg), and for both sexes combined was 3300 (95% CL: 2800 - 4500 mg/kg). All deaths occurred within one day of dosing. Adverse signs included weight loss, lethargy, coma, hypopnea, gasping, and dacryorrhea. Surviving rats showed no adverse signs by day 2. At necropsy, surviving rats showed no grossly observable lesions. Rats dying from treatment exhibited hemorrhage of the stomach and small intestine, bloody content of the small intestine and bladder, yellow liquid within the small intestine, and hyperemia of the bladder.

PubMed
DOI WoS
Journal Article

Final report on the safety assessment of PPG-2 methyl ether, PPG-3 methyl ether, and PPG-2 methyl ether acetate

Robinson V et al. 2009

Abstract  PPG-2 methyl ether, PPG-3 methyl ether, and PPG-2 methyl ether acetate are used in cosmetics as fragrance ingredients and/or solvents at concentrations of 0.4% to 2%. Propylene glycol ethers are rapidly absorbed and distributed throughout the body when introduced by inhalation or oral exposure, but the inhalation toxicity of PPG-2 methyl ether vapor, for example, is low. Aerosols, such as found with hair sprays, produce particle sizes that are not respirable. Because these ingredients are highly water-soluble, they are likely to be absorbed through the human skin only at slow rates, resulting in low blood concentrations and rapid removal by the kidney. These ingredients are not genotoxic and are not reproductive or developmental toxicants. Overall the data are sufficient to conclude that PPG-2 methyl ether, PPG-3 methyl ether, and PPG-2 methyl ether acetate are safe as used in cosmetics.

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