Vanadium Induces Oxidative Stress and Mitochondrial Quality Control Disorder in the Heart of Ducks
Xiong, Z; Xing, C; Xu, T; Yang, Y; Liu, G; Hu, G; Cao, H; Zhang, C; Guo, X; Yang, F
HERO ID
10314509
Reference Type
Journal Article
Year
2021
Language
English
PMID
| HERO ID | 10314509 |
|---|---|
| In Press | No |
| Year | 2021 |
| Title | Vanadium Induces Oxidative Stress and Mitochondrial Quality Control Disorder in the Heart of Ducks |
| Authors | Xiong, Z; Xing, C; Xu, T; Yang, Y; Liu, G; Hu, G; Cao, H; Zhang, C; Guo, X; Yang, F |
| Journal | Frontiers in Veterinary Science |
| Volume | 8 |
| Page Numbers | 756534 |
| Abstract | Vanadium (V) is an ultra-trace element presenting in humans and animals, but excessive V can cause toxic effects. Mitochondrial quality control (MQC) is an essential process for maintaining mitochondrial functions, but the relationship between V toxicity and MQC is unclear. To investigate the effects of excessive V on oxidative stress and MQC in duck hearts, 72 ducks were randomly divided into two groups, including the control group and the V group (30 mg of V/kg dry matter). The cardiac tissues were collected for the histomorphology observation and oxidative stress status evaluation at 22 and 44 days. In addition, the mRNA and protein levels of MQC-related factors were also analyzed. The results showed that excessive V could trigger vacuolar degeneration, granular degeneration, as well as mitochondrial vacuolization and swelling in myocardial cells. In addition, CAT activity was elevated in two time points, while T-SOD activity was increased in 22 days but decreased in 44 days after V treatment. Meanwhile, excessive V intake could also increase the number of Drp1 puncta, the mRNA levels of mitochondrial fission-related factors (Drp1and MFF), and protein (MFF) level, but decrease the number of Parkin puncta and the mitochondrial biogenesis (PGC-1α, NRF-1, and TFAM), mitochondrial fusion (OPA1, Mfn1, and Mfn2), and mitophagy (Parkin, PINK1, P62, and LC3B) related mRNA levels and protein (PGC-1α, Mfn1, Mfn2, PINK1) levels. Collectively, our results suggested that excessive V could induce oxidative stress and MQC disorder in the heart of ducks. |
| Doi | 10.3389/fvets.2021.756534 |
| Pmid | 34765669 |
| Wosid | WOS:000717621800001 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | vanadium; oxidative stress; mitochondrial quality control; heart; duck |