Antiplasmodial quinones from Pentas longiflora and Pentas lanceolata
Endale, M; Alao, JP; Akala, HM; Rono, NK; Eyase, FL; Derese, S; Ndakala, A; Mbugua, M; Walsh, DS; Sunnerhagen, P; Erdelyi, M; Yenesew, A
| HERO ID | 1039741 |
|---|---|
| In Press | No |
| Year | 2012 |
| Title | Antiplasmodial quinones from Pentas longiflora and Pentas lanceolata |
| Authors | Endale, M; Alao, JP; Akala, HM; Rono, NK; Eyase, FL; Derese, S; Ndakala, A; Mbugua, M; Walsh, DS; Sunnerhagen, P; Erdelyi, M; Yenesew, A |
| Journal | Planta Medica |
| Volume | 78 |
| Issue | 1 |
| Page Numbers | 31-35 |
| Abstract | The dichloromethane/methanol (1 : 1) extracts of the roots of Pentas longiflora and Pentas lanceolata showed low micromolar (IC₅₀= 0.9-3 µg/mL) IN VITRO antiplasmodial activity against chloroquine-resistant (W2) and chloroquine-sensitive (D6) strains of PLASMODIUM FALCIPARUM. Chromatographic separation of the extract of PENTAS LONGIFLORA led to the isolation of the pyranonaphthoquinones pentalongin (1) and psychorubrin (2) with IC₅₀ values below 1 µg/mL and the naphthalene derivative mollugin (3), which showed marginal activity. Similar treatment of Pentas lanceolata led to the isolation of eight anthraquinones ( 4-11, IC₅₀= 5-31 µg/mL) of which one is new (5,6-dihydroxydamnacanthol, 11), while three--nordamnacanthal (7), lucidin-ω-methyl ether (9), and damnacanthol (10)--are reported here for the first time from the genus Pentas. The compounds were identified by NMR and mass spectroscopic techniques. |
| Doi | 10.1055/s-0031-1280179 |
| Pmid | 21979929 |
| Wosid | WOS:000299109700006 |
| Url | https://www.proquest.com/scholarly-journals/antiplasmodial-quinones-pentas-longiflora/docview/1663603879/se-2?accountid=171501 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Source: Web of Science 000299109700006 |
| Is Public | Yes |
| Language Text | English |
| Keyword | Pentas longiflora; Pentas lanceolata; Rubiaceae; anthraquinone 5,6-dihydroxydamnacanthol; pyranonaphthoquinone; malaria |
| Is Qa | No |