Subdivision of uncertainty factors to allow for toxicokinetics and toxicodynamics
Renwick, A
HERO ID
1060819
Reference Type
Journal Article
Year
1999
Language
English
| HERO ID | 1060819 |
|---|---|
| In Press | No |
| Year | 1999 |
| Title | Subdivision of uncertainty factors to allow for toxicokinetics and toxicodynamics |
| Authors | Renwick, A |
| Journal | Human and Ecological Risk Assessment |
| Volume | 5 |
| Issue | 5 |
| Page Numbers | 1035-1050 |
| Abstract | Tenfold uncertainty factors have been used in risk assessment for about 40 years to allow for species differences and inter-individual variability. Each factor has to allow for toxicokinetic and toxicodynamic differences. Subdividing the 10-fold factors into kinetic and dynamic defaults, which when multiplied give a product of 10, offers a number of advantages. A major advantage is that chemical-specific data can be introduced to replace one or more of the default subfactors, hence contributing to a chemical-related overall factor. Subdivision of the 10-fold factors also facilitates analysis of the appropriateness of the overall 10-fold defaults, and the development of a more refined approach to the use of uncertainty factors. |
| Doi | 10.1080/10807039991289329 |
| Wosid | WOS:000083522800017 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | uncertainty factors; safety factors; acceptable daily intake; species differences; human variability; reference dose |