Enantiomeric resolution of new triazole compounds by high-performance liquid chromatography
Lv, C; Jia, G; Zhu, W; Qiu, J; Wang, X; Zhou, Z
| HERO ID | 1071107 |
|---|---|
| In Press | No |
| Year | 2007 |
| Title | Enantiomeric resolution of new triazole compounds by high-performance liquid chromatography |
| Authors | Lv, C; Jia, G; Zhu, W; Qiu, J; Wang, X; Zhou, Z |
| Journal | Journal of Separation Science |
| Volume | 30 |
| Issue | 3 |
| Page Numbers | 344-351 |
| Abstract | Cellulose tris(3,5-dimethylphenylcarbamate) (CDMPC) was synthesized and coated on aminopropylsilica to prepare a chiral stationary phase (CSP). HPLC methods were developed for the direct enantioseparation of 12 chiral triazole compounds on the CSP. The separations were made using normal phase methodology with a mobile phase consisting of n-hexane-alcohol (ethanol, 1-propanol, 1-butanol, 2-propanol, and t-butanol) in various portions. The column temperatures were studied for the optimization of the resolutions. The effects of structural features of the solutes on the discrimination between the enantiomers were examined. Baseline separation was easily obtained in many cases. |
| Doi | 10.1002/jssc.200600282 |
| Pmid | 17396592 |
| Wosid | WOS:000244768400008 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Scopus URL: https://www.scopus.com/inward/record.uri?eid=2-s2.0-33847681306&doi=10.1002%2fjssc.200600282&partnerID=40&md5=c3fc33cfd1c073a789ff5e0093ccad9d |
| Is Public | Yes |
| Language Text | English |
| Keyword | Chiral triazole; Enantiomer separation; HPLC; Polysaccharide carbamate phase; Enantiomers; High performance liquid chromatography; Optimization; Phase separation; Synthesis (chemical); Temperature; Chiral triazole; Enantiomer separation; Polysaccharide carbamate phase; Polysaccharides; 2 propanol; alcohol; butanol; cellulose tris(3,5 dimethylphenylcarbamate); hexane; propanol; tert butyl alcohol; triazole derivative; article; chemical structure; chirality; controlled study; enantiomer; high performance liquid chromatography; priority journal; process optimization; separation technique; solute; temperature |
| Is Qa | No |