Quantifying uncertainty in a risk assessment using human data
Fayerweather, WE; Collins, JJ; Schnatter, AR; Hearne, FT; Menning, RA; Reyner, DP
HERO ID
11426
Reference Type
Journal Article
Year
1999
Language
English
PMID
| HERO ID | 11426 |
|---|---|
| In Press | No |
| Year | 1999 |
| Title | Quantifying uncertainty in a risk assessment using human data |
| Authors | Fayerweather, WE; Collins, JJ; Schnatter, AR; Hearne, FT; Menning, RA; Reyner, DP |
| Journal | Risk Analysis |
| Volume | 19 |
| Issue | 6 |
| Page Numbers | 1077-1090 |
| Abstract | A call for risk assessment approaches that better characterize and quantify uncertainty has been made by the scientific and regulatory community. This paper responds to that call by demonstrating a distributional approach that draws upon human data to derive potency estimates and to identify and quantify important sources of uncertainty. The approach is rooted in the science of decision analysis and employs an influence diagram, a decision tree, probabilistic weights, and a distribution of point estimates of carcinogenic potency. Its results estimate the likelihood of different carcinogenic risks (potencies) for a chemical under a specific scenario. For this exercise, human data on formaldehyde were employed to demonstrate the approach. Sensitivity analyses were performed to determine the relative impact of specific levels and alternatives on the potency distribution. The resulting potency estimates are compared with the results of an exercise using animal data on formaldehyde. The paper demonstrates that distributional risk assessment is readily adapted to situations in which epidemiologic data serve as the basis for potency estimates. Strengths and weaknesses of the distributional approach are discussed. Areas for further application and research are recommended. |
| Doi | 10.1111/j.1539-6924.1999.tb01129.x |
| Pmid | 10765448 |
| Wosid | CCC:000084295700005 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |