Probabilistic approach for the risk assessment of nanomaterials: A case study for graphene nanoplatelets
Spinazze, A; Cattaneo, A; Borghi, F; Del Buono, L; Campagnolo, D; Rovelli, S; Cavallo, DM
| HERO ID | 12033094 |
|---|---|
| In Press | No |
| Year | 2019 |
| Title | Probabilistic approach for the risk assessment of nanomaterials: A case study for graphene nanoplatelets |
| Authors | Spinazze, A; Cattaneo, A; Borghi, F; Del Buono, L; Campagnolo, D; Rovelli, S; Cavallo, DM |
| Journal | International Journal of Hygiene and Environmental Health |
| Volume | 222 |
| Issue | 1 |
| Page Numbers | 76-83 |
| Abstract | An experimental probabilistic approach for health risk assessment was applied for graphene nanoplatelets (GNPs). The hazard assessment indicated a low level of toxicity for the GNPs. The benchmark dose method, based on sub-chronic and chronic inhalation exposure studies, was used to quantify a guidance value (BMC(h)) for occupational inhalation exposure to GNPs, expressed as a lognormal distribution with a geometric mean +/- geometric standard deviation of 0.212 +/- 7.79 mg/m(3) and 9.37 x 10(4) +/- 7.6 particle/cm(3). Exposure scenarios (ES) were defined based on the scientific literature for large-scale production (ES1) and manufacturing (ES2) of GNPs; a third ES, concerning in-lab handling of GNPs (ES3) was based on results of experiments performed for this study. A probability distribution function was then assumed for each ES. The risk magnitude was calculated using a risk characterization ratio (RCR), defined as the ratio of the exposure distributions and the BMC(h) distribution. All three ES resulted in RCR distributions >/=1 (i.e. risk present); however, none of the ES had a statistically significant level of risk at a 95% confidence interval. A sensitivity analysis indicated that approximately 75% of the variation in the RCR distributions was due to uncertainties in the BMC(h) calculation. |
| Doi | 10.1016/j.ijheh.2018.08.011 |
| Url | https://www.ncbi.nlm.nih.gov/pubmed/30150162 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Keyword | Dose-Response Relationship, Drug; Graphite/toxicity; Models, Statistical; Nanostructures/adverse effects; Occupational Exposure/adverse effects; Risk Assessment; Engineered nanomaterials; Graphene; Nanotechnology; Occupational exposure; Occupational health |