Development and in vitro/in vivo evaluation of etodolac controlled porosity osmotic pump tablets
Abd-Elbary, A; Tadros, MI; Alaa-Eldin, AA
HERO ID
1249806
Reference Type
Journal Article
Year
2011
Language
English
PMID
| HERO ID | 1249806 |
|---|---|
| In Press | No |
| Year | 2011 |
| Title | Development and in vitro/in vivo evaluation of etodolac controlled porosity osmotic pump tablets |
| Authors | Abd-Elbary, A; Tadros, MI; Alaa-Eldin, AA |
| Journal | AAPS PharmSciTech |
| Volume | 12 |
| Issue | 2 |
| Page Numbers | 485-495 |
| Abstract | The aim of the current work was the design and evaluation of etodolac controlled porosity osmotic pump (CPOP) tablets exhibiting zero-order release kinetics. Variables influencing the design of (1) core tablets viz., (a) osmogent type (sodium chloride, potassium chloride, mannitol, and fructose) and (b) drug/osmogent ratio (1:0.25, 1:0.50, and 1:0.75), and (2) CPOP tablets viz., (a) coating solution composition, (b) weight gain percentage (1-5%, w/w), and (c) pore former concentration (5%, 10%, and 20%, v/v), were investigated. Statistical analysis and kinetic modeling of drug release data were estimated. Fructose-containing core tablets showed significantly (P < 0.05) more retarded drug release rates. An inverse correlation was observed between drug/fructose ratio and drug release rate. Coating of the optimum core tablets (F4) with a mixture of cellulose acetate solution (3%, w/v), diethyl phthalate, and polyethylene glycol 400 (85:10:5, v/v, respectively) till a 4% w/w weight gain enabled zero-order sustained drug delivery over 24 h. Scanning electron microscopy micrographs of coating membrane confirmed pore formation upon contact with dissolution medium. When compared to the commercial immediate-release Napilac® capsules, the optimum CPOP tablets (F4-34) provided enhanced bioavailability and extended duration of effective etodolac plasma concentration with minimum expected potential for side effects in healthy volunteers. |
| Doi | 10.1208/s12249-011-9608-z |
| Pmid | 21479749 |
| Wosid | WOS:000292688700005 |
| Url | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3134663/ |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Source: Web of Science WOS:000292688700005 |
| Is Public | Yes |
| Language Text | English |
| Keyword | cellulose acetate; controlled porosity osmotic pump; etodolac; osmogent; zero order |
| Is Qa | No |