Serum perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS) concentrations and liver function biomarkers in a population with elevated PFOA exposure
Gallo, V; Leonardi, G; Genser, B; Lopez-Espinosa, MJ; Frisbee, SJ; Karlsson, L; Ducatman, AM; Fletcher, T
HERO ID
1276142
Reference Type
Journal Article
Year
2012
Language
English
PMID
| HERO ID | 1276142 |
|---|---|
| In Press | No |
| Year | 2012 |
| Title | Serum perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS) concentrations and liver function biomarkers in a population with elevated PFOA exposure |
| Authors | Gallo, V; Leonardi, G; Genser, B; Lopez-Espinosa, MJ; Frisbee, SJ; Karlsson, L; Ducatman, AM; Fletcher, T |
| Journal | Environmental Health Perspectives |
| Volume | 120 |
| Issue | 5 |
| Page Numbers | 655-660 |
| Abstract | <strong>BACKGROUND: </strong>Perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS) persist in the environment and are found in relatively high concentrations in animal livers. Studies in humans have reported inconsistent associations between PFOA and liver enzymes.<br /><br /><strong>OBJECTIVES: </strong>We examined the cross-sectional association between serum PFOA and PFOS concentrations with markers of liver function in adults.<br /><br /><strong>METHODS: </strong>The C8 Health Project collected data on 69,030 persons; of these, a total of 47,092 adults were included in the present analysis. Linear regression models were fitted for natural log (ln)-transformed values of alanine transaminase (ALT), γ-glutamyltransferase (GGT), and direct bilirubin on PFOA, PFOS, and potential confounders. Logistic regression models were fitted comparing deciles of PFOA or PFOS in relation to high biomarker levels. A multilevel analysis comparing the evidence for association of PFOA with liver function at the individual level within water districts to that at the population level between water districts was also performed.<br /><br /><strong>RESULTS: </strong>ln-PFOA and ln-PFOS were associated with ln-ALT in linear regression models [PFOA: coefficient, 0.022; 95% confidence interval (CI): 0.018, 0.025; PFOS: coefficient, 0.020; 95% CI: 0.014, 0.026] and with raised ALT in logistic regression models [with a steady increase in the odds ratio (OR) estimates across deciles of PFOA and PFOS; PFOA: OR = 1.10; 95% CI: 1.07, 1.13; PFOS: OR = 1.13; 95% CI: 1.07, 1.18]. There was less consistent evidence of an association of PFOA and GGT or bilirubin. The relationship with bilirubin appears to rise at low levels of PFOA and to fall again at higher levels.<br /><br /><strong>CONCLUSIONS: </strong>These results show a positive association between PFOA and PFOS concentrations and serum ALT level, a marker of hepatocellular damage. |
| Doi | 10.1289/ehp.1104436 |
| Pmid | 22289616 |
| Wosid | WOS:000303546000027 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Source: Web of Science WOS:000303546000027 |
| Is Public | Yes |
| Language Text | English |
| Keyword | C8; cross-sectional study; liver function biomarkers; PFOA; PFOS; population-based survey |
| Is Qa | No |