Protective effect of naringenin against lead-induced oxidative stress in rats
Wang, J; Yang, Z; Lin, L; Zhao, Z; Liu, Z; Liu, X
HERO ID
1401625
Reference Type
Journal Article
Year
2012
Language
English
PMID
| HERO ID | 1401625 |
|---|---|
| In Press | No |
| Year | 2012 |
| Title | Protective effect of naringenin against lead-induced oxidative stress in rats |
| Authors | Wang, J; Yang, Z; Lin, L; Zhao, Z; Liu, Z; Liu, X |
| Journal | Biological Trace Element Research |
| Volume | 146 |
| Issue | 3 |
| Page Numbers | 354-359 |
| Abstract | Oxidative stress is thought to be involved in lead-induced toxicity. The aim of this study was to investigate the possible protective role of naringenin on lead-induced oxidative stress in the liver and kidney of rats. In the present investigation, lead acetate (500 mg Pb/L) was administered orally for 8 weeks to induce hepatotoxicity and nephrotoxicity. The levels of hepatic and renal markers such as alanine aminotransferase, aspartate aminotransferase, urea, uric acid, and creatinine were significantly (P < 0.05) increased following lead acetate administration. Lead-induced oxidative stress in liver and kidney tissue was indicated by a significant (P < 0.05) increase in the level of maleic dialdehyde and decreased levels of reduced glutathione, superoxide dismutase, catalase, and glutathione peroxidase. Naringenin markedly attenuated lead-induced biochemical alterations in serum, liver, and kidney tissues (P < 0.05). The present study suggests that naringenin shows antioxidant activity and plays a protective role against lead-induced oxidative damage in the liver and kidney of rats. |
| Doi | 10.1007/s12011-011-9268-6 |
| Pmid | 22109809 |
| Wosid | WOS:000303407900010 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | Lead; Naringenin; Oxidative stress; Antioxidants; Liver; Kidney |