Effect of acclimation to caging on nephrotoxic response of rats to uranium
Damon, EG; Eidson, AF; Hobbs, CH; Hahn, FF
HERO ID
1421067
Reference Type
Journal Article
Year
1986
Language
English
PMID
| HERO ID | 1421067 |
|---|---|
| In Press | No |
| Year | 1986 |
| Title | Effect of acclimation to caging on nephrotoxic response of rats to uranium |
| Authors | Damon, EG; Eidson, AF; Hobbs, CH; Hahn, FF |
| Journal | Laboratory Animal Science |
| Volume | 36 |
| Issue | 1 |
| Page Numbers | 24-27 |
| Abstract | Animal studies of the toxicity and metabolism of radionuclides and chemicals often require housing of rats in metabolism cages for excreta collection. Response of rats to toxic substances may be affected by environmental factors such as the type of cage used. Dose-response studies were conducted to assess the effects of two types of cages on the nephrotoxic response of rats to uranium from implanted refined uranium ore (yellowcake). The LD50/21 days was 6 mg of uranium ore per kilogram body weight (6 mg U/kg). The 95% confidence limit (C.L.) was 3-8 mg U/kg for rats housed in metabolism cages beginning on the day of implantation (naive rats). However, for rats housed in metabolism cages for 21 days before implantation (acclimated rats) the LD50/21 days was 360 mg U/kg (95% C.L. = 220-650 mg U/kg), which was the same value obtained for rats housed continuously in polycarbonate cages. This significant difference (P less than 0.01) in response of naive rats compared to response of acclimated rats appeared related to a significantly lower water consumption by the naive rats. |
| Pmid | 3959530 |
| Wosid | WOS:A1986A281200004 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Source: Web of Science WOS:A1986A281200004 |
| Is Public | Yes |
| Language Text | English |
| Keyword | <?xml version="1.0" encoding="UTF-8"?><kw>Radiation-Radiation Effects and Protective Measures</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Ecology</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Biochemical Studies-Minerals</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Metabolism-Minerals</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Nutrition-General Dietary Studies</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Urinary System and External Secretions-Pathology</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Toxicology-General</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Muridae</kw> |
| Relationship(s) |
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