A study of the metabolic pathway and mechanism of butyl benzyl phthalate
Li, WL; Wang, J; Yang, B; Ji, YB; Lang, L
| HERO ID | 1464945 |
|---|---|
| Year | 2008 |
| Title | A study of the metabolic pathway and mechanism of butyl benzyl phthalate |
| Book Title | 2008 proceedings of Information Technology and Environmental System Sciences, vol. 1 |
| Authors | Li, WL; Wang, J; Yang, B; Ji, YB; Lang, L |
| Publisher Text | Dian zi gong ye chu ban she |
| City | Beijing, China |
| Page Numbers | 527-532 |
| Abstract | In order to know the metabolic mechanism of Butyl benzyl Phthalate, The methods of HPLC and HPLC-MS were used to identify metabolites in mice urine and liver homogenate. The metabolites of butyl benzyl phthalate in liver were monobutyl phthalate and methanoyl phthalate. Six metabolites of butyl benzyl phthalate were found in urine: phthalic acid, hippuric acid, monobutyl phthalate, benzyl phthalate, glucuronyl-monobutyl phthalate, glucuronyl-benzyl phthalate. The metabolic pathway of butyl benzyl phthalate in vivo was that butyl benzyl phthalate was hydrolyzed into the phthalic acid, monobutyl phthalate and benzyl phthalate. Partial phthalic acid became into benzoic acid by decarboxylizing. Then benzoic acid conjugated endogenous glycin and benzoyl glycocoll was generated. Monobutyl phthalate and benzyl phthalate conjugated endogenous beta-D-glucuronic acid and produced the glucurony-monobutyl phthalate and glucuronyl-benzyl phthalate. |
| Wosid | WOS:000257017700105 |
| Is Certified Translation | No |
| Dupe Override | No |
| Conference Location | Jiaozuo, China |
| Isbn | 978-7-121-06302-2 |
| Conference Name | International Conference on Information Technology and Environmental System Sciences: ITESS 2008 |
| Conference Date | May 15-17, 2008 |
| Comments | Source: Web of Science WOS:000257017700105 Journal:2008 PROCEEDINGS OF INFORMATION TECHNOLOGY AND ENVIRONMENTAL SYSTEM SCIENCES: ITESS 2008, VOL 1 |
| Is Public | Yes |
| Keyword | butyl benzyl phthalate; environmental estrogens; metabolic mechanism; HPLC/MS |