Evaluation of the C9 aromatic hydrocarbons for mutagenic potential (final report) with two cover letters dated 012988 and 012688
HERO ID
1481423
Reference Type
Technical Report
Subtype
TSCA Submission
Year
1988
Language
English
| HERO ID | 1481423 |
|---|---|
| Material Type | TSCA Submission |
| Year | 1988 |
| Title | Evaluation of the C9 aromatic hydrocarbons for mutagenic potential (final report) with two cover letters dated 012988 and 012688 |
| Authoring Organization | International Research & Development Corporation |
| Publisher Text | American Petroleum Institute |
| City | Washington DC |
| Abstract | Four groups of 15 male and 15 female Sprague-Dawley rats were exposed, six hours a day for five consecutive days, to either clean air or 153, 471, 1540 ppm of C9 aromatic hydrocarbon vapors. A fifth group of five males and five females served as positive controls and received an injection of 40/mg/kg cyclophosphoride. Five males and five females from each exposure group were injected with 4 mg/kg colchincine, six hours later (which was 6, 24, and 48 hours after the last exposure), the animlas were sacrificed, bone marrow collected, and chormosoome spreads prepared. The positive control animals were evaluated at 24-hour intervals. Under the exposure conditions for this study, C9 aromatic hydrocarbon vapor did not induce chromosome or chromatid aberrations at any exposure level, and therefore, was considered to be non-mutagenic. |
| Report Number | FYI-AX-0288-0589 |
| Ntis Number | OTS00005890 |
| Tscats Number | 303658 |
| Url | http://yosemite.epa.gov/oppts/epatscat8.nsf/ReportSearchView/50D02968C8159FF285256930004DE266 |
| Is Certified Translation | No |
| Dupe Override | No |
| Number Of Pages | 64 |
| Is Public | Yes |
| Language Text | English |
| Relationship(s) |
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