(Residue and toxicity of beclotiamine in chickens.)
Matuzawa, T; Yamazaki, M; Saski, M; Kitano, N; Suzuki, Y
| HERO ID | 1483212 |
|---|---|
| Year | 1971 |
| Title | (Residue and toxicity of beclotiamine in chickens.) |
| Authors | Matuzawa, T; Yamazaki, M; Saski, M; Kitano, N; Suzuki, Y |
| Volume | 8 |
| Page Numbers | 144-149 |
| Abstract | HEEP COPYRIGHT: BIOL ABS. Beclotiamine-naphthalene disulfonate, a coccidiostat, was fed to 1-day-old White Leghorn male chicks for 8 wk in doses of 125 ppm, 500 ppm and 1000 ppm in the diet. As controls, non-medicated diet or diets containing thiamine-NDS at 125 ppm and 100 ppm were fed to the chickens. Quantities equivalent to about 0.4 ppm and 0.04 ppm and beclotiamine-HC1 were detected in liver and muscle, respectively, of the birds fed at the dose of 125 ppm in the diet. When the dose of beclotiamine was increased to 4 to 8 times greater, no accumulation of the coccidiosatat occurred in the tissues throughout the entire 56 days of the medication. Beclotiamine rapidly disappeared from the tissues once the compound was withdrawm from the diet. Neither growth depression nor decrease in thiamine levels in the liver occurred by administration of beclotiamine. Weights of liver, heart, brain, spleen, adrenal gland, kidney and testis were not influenced by administration of beclotiamine or thiamine. Serum acid phosphatase, alkaline phosphatase, glutamine-pyruvic transaminase and glutamic oxaloacetic transaminase activities and serum protein, cholesterol, and serum glucose were all within the normal range. No histophathological changes were observed in the liver. |
| Report Number | HEEP/73/01208 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Journal: JAP POULT SCI ISSN: |
| Is Public | Yes |