Molecular recognition using receptor-free nanomechanical infrared spectroscopy based on a quantum cascade laser
Kim, S; Lee, D; Liu, X; Van Neste, C; Jeon, S; Thundat, T
HERO ID
1506888
Reference Type
Journal Article
Year
2013
Language
English
PMID
| HERO ID | 1506888 |
|---|---|
| In Press | No |
| Year | 2013 |
| Title | Molecular recognition using receptor-free nanomechanical infrared spectroscopy based on a quantum cascade laser |
| Authors | Kim, S; Lee, D; Liu, X; Van Neste, C; Jeon, S; Thundat, T |
| Journal | Scientific Reports |
| Volume | 3 |
| Page Numbers | 1111 |
| Abstract | Speciation of complex mixtures of trace explosives presents a formidable challenge for sensors that rely on chemoselective interfaces due to the unspecific nature of weak intermolecular interactions. Nanomechanical infrared (IR) spectroscopy provides higher selectivity in molecular detection without using chemoselective interfaces by measuring the photothermal effect of adsorbed molecules on a thermally sensitive microcantilever. In addition, unlike conventional IR spectroscopy, the detection sensitivity is drastically enhanced by increasing the IR laser power, since the photothermal signal comes from the absorption of IR photons and nonradiative decay processes. By using a broadly tunable quantum cascade laser for the resonant excitation of molecules, we increased the detection sensitivity by one order of magnitude compared to the use of a conventional IR monochromator. Here, we demonstrate the successful speciation and quantification of picogram levels of ternary mixtures of similar explosives (trinitrotoluene (TNT), cyclotrimethylene trinitramine (RDX), and pentaerythritol tetranitrate (PETN)) using nanomechanical IR spectroscopy. |
| Doi | 10.1038/srep01111 |
| Pmid | 23346368 |
| Wosid | WOS:000314091000004 |
| Url | http://www.nature.com/articles/srep01111 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Journal: Scientific reports ISSN: 2045-2322 |
| Is Public | Yes |
| Language Text | English |