Intrathecal injection of GluR6 antisense oligodeoxynucleotides alleviates acute inflammatory pain of rectum in rats
Zhang, WG; Zhang, LC; Peng, ZD; Zeng, YM
| HERO ID | 1514001 |
|---|---|
| In Press | No |
| Year | 2009 |
| Title | Intrathecal injection of GluR6 antisense oligodeoxynucleotides alleviates acute inflammatory pain of rectum in rats |
| Authors | Zhang, WG; Zhang, LC; Peng, ZD; Zeng, YM |
| Journal | Neuroscience Bulletin |
| Volume | 25 |
| Issue | 5 |
| Page Numbers | 319-323 |
| Abstract | <strong>OBJECTIVE: </strong>To investigate whether the kainate (KA) receptor subunit GluR6 is involved in the acute inflammatory pain.<br /><br /><strong>METHODS: </strong>Formalin was injected into the mucosa of rectum in Sprague-Dawley rats to induce visceral pain. The antisense oligodeoxynucleotides (ODNs) of GluR6 were injected once per day for 3 d before formalin injection, after which GluR6 protein level was examined by immunoblotting method. The change of visceral pain was also investigated.<br /><br /><strong>RESULTS: </strong>The expression of GluR6 in the spinal cord of rats increased after the formalin injection. Moreover, pre-treatment of GluR6 antisense ODNs could suppress GluR6 expression in the spinal cord of rats and decrease the scores of visceral pain at 45 min following formalin injection.<br /><br /><strong>CONCLUSION: </strong>Kainate receptor subunit GluR6 plays an important role in the visceral pain induced by injection of formalin into the wall of rectum. GluR6 may serve as a potential target for the treatment of acute inflammatory visceral pain. |
| Doi | 10.1007/s12264-009-0326-4 |
| Pmid | 19784088 |
| Wosid | WOS:000208089300010 |
| Url | <Go to ISI>://WOS:000208089300010 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | acute inflammatory pain; rectum; GluR6; spinal cord |