Regiospecific synthesis of 5-trichloromethyl-1H-pyrazole and 1H-pyrazole-5-carboxylic ester derivatives
Moura, S; Flores, AFC; Paula, FR; Pinto, E; Machado, P; Martins, MAP
| HERO ID | 1558952 |
|---|---|
| In Press | No |
| Year | 2008 |
| Title | Regiospecific synthesis of 5-trichloromethyl-1H-pyrazole and 1H-pyrazole-5-carboxylic ester derivatives |
| Authors | Moura, S; Flores, AFC; Paula, FR; Pinto, E; Machado, P; Martins, MAP |
| Journal | Letters in Organic Chemistry |
| Volume | 5 |
| Issue | 2 |
| Page Numbers | 91-97 |
| Abstract | Reaction of 1,1,1-trichloro-4-methoxy-3-penten-2-one (1) with hydrazines (2a-h) (NH2NHR, R = H, Me, t-Bu, Ph, 4-NO2-C6H4, C6F5, CO2Me, CONH2) under differing conditions regiospecifically affords different pyrazole derivatives, 3-methyl-5- trichloromethyl-5-hydroxy-4,5-dihydropyrazoles (3a, d-h), 3-methyl-5-trichloromethyl-1H-pyrazoles (4a,b,d-g) and 5-carboxyethyl-3-methyl-1H-pyrazoles (5a-e). The structural assignments were based on the analysis of their H-1/C-13 NMR and ESI-MS data. |
| Wosid | WOS:000254079000005 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Source: Web of Science WOS:000254079000005 |
| Is Public | Yes |
| Keyword | pyrazoles; trichloromethyl-1H-pyrazoles; 1,1,1-trichloro-4-alkoxy-3-alken-2-ones; cyclocondensation [CCC plus NN] |