Mouse models for human lung cancer
Meuwissen, R; Berns, A
HERO ID
1576434
Reference Type
Journal Article
Subtype
Review
Year
2005
Language
English
PMID
| HERO ID | 1576434 |
|---|---|
| Material Type | Review |
| In Press | No |
| Year | 2005 |
| Title | Mouse models for human lung cancer |
| Authors | Meuwissen, R; Berns, A |
| Journal | Genes & Development |
| Volume | 19 |
| Issue | 6 |
| Page Numbers | 643-664 |
| Abstract | In recent years several new mouse models for lung cancer have been described. These include models for both non-small-cell lung cancer (NSCLC) and small-cell lung cancer (SCLC). Tumorigenesis in these conditional mouse tumor models can be initiated in adult mice through Cre-recombinase-induced activation of oncogenic mutations in a subset of the cells. They present a marked improvement over mouse models that depend on carcinogen induction of tumors. These models permit us to study the consecutive steps involved in initiation and progression and allow us to address questions like the cell of origin, and the role of cancer stem cells in the maintenance of these tumors. They now need to be validated as suitable preclinical models for intervention studies in which questions with respect to therapy response and resistance can be addressed. |
| Doi | 10.1101/gad.1284505 |
| Pmid | 15769940 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |