Evolving concepts in lung carcinogenesis
Gomperts, BN; Spira, A; Massion, PP; Walser, TC; Wistuba, II; Minna, JD; Dubinett, SM
HERO ID
1597198
Reference Type
Journal Article
Subtype
Review
Year
2011
Language
English
PMID
| HERO ID | 1597198 |
|---|---|
| Material Type | Review |
| In Press | No |
| Year | 2011 |
| Title | Evolving concepts in lung carcinogenesis |
| Authors | Gomperts, BN; Spira, A; Massion, PP; Walser, TC; Wistuba, II; Minna, JD; Dubinett, SM |
| Journal | Seminars in Respiratory and Critical Care Medicine |
| Volume | 32 |
| Issue | 1 |
| Page Numbers | 32-43 |
| Abstract | Lung carcinogenesis is a complex, stepwise process that involves the acquisition of genetic mutations and epigenetic changes that alter cellular processes, such as proliferation, differentiation, invasion, and metastasis. Here, we review some of the latest concepts in the pathogenesis of lung cancer and highlight the roles of inflammation, the "field of cancerization," and lung cancer stem cells in the initiation of the disease. Furthermore, we review how high throughput genomics, transcriptomics, epigenomics, and proteomics are advancing the study of lung carcinogenesis. Finally, we reflect on the potential of current in vitro and in vivo models of lung carcinogenesis to advance the field and on the areas of investigation where major breakthroughs will lead to the identification of novel chemoprevention strategies and therapies for lung cancer. |
| Doi | 10.1055/s-0031-1272867 |
| Pmid | 21500122 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |