Evidence for type II cells as cells of origin of K-Ras-induced distal lung adenocarcinoma: Supporting information
Xu, X; Rock, JR; Lu, Y; Futtner, C; Schwab, B; Guinney, J; Hogan, BL; Onaitis, MW
HERO ID
1597203
Reference Type
Journal Article
Subtype
Supplemental Data
Year
2012
Language
English
| HERO ID | 1597203 |
|---|---|
| Material Type | Supplemental Data |
| In Press | No |
| Year | 2012 |
| Title | Evidence for type II cells as cells of origin of K-Ras-induced distal lung adenocarcinoma: Supporting information |
| Authors | Xu, X; Rock, JR; Lu, Y; Futtner, C; Schwab, B; Guinney, J; Hogan, BL; Onaitis, MW |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Volume | 109 |
| Issue | 13 |
| Page Numbers | 4910-4915 |
| Abstract | Identifying the cells of origin of lung cancer may lead to new therapeutic strategies. Previous work has focused upon the putative bronchoalveolar stem cell at the bronchioalveolar duct junction as a cancer cell of origin when a codon 12 K-Ras mutant is induced via adenoviral Cre inhalation. In the present study, we use two "knock-in" Cre-estrogen receptor alleles to inducibly express K-RasG12D in CC10(+) epithelial cells and Sftpc(+) type II alveolar cells of the adult mouse lung. Analysis of these mice identifies type II cells, Clara cells in the terminal bronchioles, and putative bronchoalveolar stem cells as cells of origin for K-Ras-induced lung hyperplasia. However, only type II cells appear to progress to adenocarcinoma. |
| Url | http://www.pnas.org/content/suppl/2012/03/11/1112499109.DCSupplemental |
| Is Certified Translation | No |
| Dupe Override | 1597203 |
| Is Public | Yes |
| Language Text | English |
| Relationship(s) |
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