New and expedient determination of atenolol in biological samples
Malbica, JO; Monson, KR
| HERO ID | 1616342 |
|---|---|
| In Press | No |
| Year | 1975 |
| Title | New and expedient determination of atenolol in biological samples |
| Authors | Malbica, JO; Monson, KR |
| Journal | Journal of Pharmaceutical Sciences |
| Volume | 64 |
| Issue | 12 |
| Page Numbers | 1992-1994 |
| Abstract | A method is described for the GLC determination of atenolol BP in plasma and urine. Extraction is accomplished under dehydrating conditions, and interfering impurities are removed by using an acidified cyclohexane-isopropanol mixture (2:1) and charcoal-treated paper disks. The drug thus isolated appears to react more efficiently with heptafluorobutyric anhydride, increasing the sensitivity of GLC electron-capture analysis. Concentrations as low as 0.02 mug/ml were measured using 0.5-ml aliquots of plasma or 0.1 ml of urine. Amino alcohols such as atenolol may form hydrates or alcoholates, precluding complete derivatization with heptafluorobutyric anhydride. |
| Doi | 10.1002/jps.2600641219 |
| Pmid | 1511 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |