Effects of inhaled 1-bromopropane vapor on rat metabolism
Ishidao, T; Kunugita, N; Fueta, Y; Arashidani, K; Hori, H
HERO ID
1717491
Reference Type
Journal Article
Year
2002
Language
English
PMID
| HERO ID | 1717491 |
|---|---|
| In Press | No |
| Year | 2002 |
| Title | Effects of inhaled 1-bromopropane vapor on rat metabolism |
| Authors | Ishidao, T; Kunugita, N; Fueta, Y; Arashidani, K; Hori, H |
| Journal | Toxicology Letters |
| Volume | 134 |
| Issue | 1-3 |
| Page Numbers | 237-243 |
| Abstract | Wistar male rats were exposed to 1-bromopromane (1-BP) vapor for 6 h a day, 5 days a week, for 3 and 4 weeks (1500 ppm) and 1 day, and 4 and 12 weeks (700 ppm). After the exposures, 1-BP and its metabolites were measured temporally. In the samples obtained from the 700 ppm exposures, hematological and biochemical examinations in blood and measurements of hepatic cytochromes P450 were carried out. 1-BP in blood decreased rapidly to the detection limit within 0.7 h. On the other hand, bromine ion persisted longer in both blood and urine; the biological half-life of bromine ion was 4.7-15.0 days in blood and 5.0-7.5 days in urine. Glycidol was detected in the urine samples. Based on the experimental results, the metabolic pathway of 1-BP was discussed. Hepatic cytochromes P450, aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in blood decreased significantly with 1-BP exposure, but other enzyme activities did not differ significantly. |
| Doi | 10.1016/S0378-4274(02)00171-6 |
| Pmid | 12191883 |
| Wosid | WOS:000178323600030 |
| Url | http://www.sciencedirect.com/science/article/pii/S0378427402001716 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Source: Web of Science WOS:000178323600030 |
| Is Public | Yes |
| Language Text | English |
| Keyword | 1-bromopropane; bromine ion; inhalation; cytochromes P450 |
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