The oxidative metabolism of 1-bromopropane in the rat
Jones, AR; Walsh, DA
HERO ID
1717683
Reference Type
Journal Article
Year
1979
Language
English
PMID
| HERO ID | 1717683 |
|---|---|
| In Press | No |
| Year | 1979 |
| Title | The oxidative metabolism of 1-bromopropane in the rat |
| Authors | Jones, AR; Walsh, DA |
| Journal | Xenobiotica |
| Volume | 9 |
| Issue | 12 |
| Page Numbers | 763-772 |
| Abstract | 1. The metabolism of 1-bromopropane in the rat has been re-investigated. The previously known metabolites have been isolated and confirmed as the three mercapturic acids N-acetyl-S-propyl cysteine, N-acetyl-S-propyl cysteine-S-oxide and N-acetyl-S-(2-hydroxypropyl)cysteine. 2. Three further metabolites have been isolated from the urine of rats treated with 4-bromopropane. These have been identified as 3-bromopropionic acid and the mercapturic acids N-acetyl-S-(3-hydroxypropyl)cysteine and N-acetyl-S-(2-carboxyethyl)cysteine. 3. The metabolites of 3-bromopropanol and 3-chloropropanol in the rat have been shown to be the mercapturic acids N-acetyl-S-(3-hydroxypropyl)cysteine and N-acetyl-S-(2-carboxyethyl)cysteine and the corresponding 2-carboxyethyl halide. 4. Studies with 1-bromopropane and the 3-halopropanols in vitro indicate that oxidation of C3 and C2 of 1-bromopropane occurs before conjugation of the alkyl group with glutathione. The implications of these studies are discussed in relation to the mechanism of the biosynthesis of the S-(2-hydroxyalkyl)mercapturic acid metabolites derived from the alkyl halides. |
| Doi | 10.3109/00498257909042344 |
| Pmid | 532220 |
| Wosid | WOS:A1979JB39500006 |
| Url | http://www.ncbi.nlm.nih.gov/pubmed/532220 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Source: Web of Science WOS:A1979JB39500006 |
| Is Public | Yes |
| Language Text | English |
| Keyword | Acetylcysteine/biosynthesis; Animals; Propane/analogs & derivatives/metabolism |
| Relationship(s) |
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