Cancer incidence in a chlorochemical plant in Isère, France: an occupational cohort study, 1979-2002
Bonneterre, V; Mathern, G; Pelen, O; Balthazard, AL; Delafosse, P; Mitton, N; Colonna, M
HERO ID
1788554
Reference Type
Journal Article
Year
2012
Language
English
PMID
| HERO ID | 1788554 |
|---|---|
| In Press | No |
| Year | 2012 |
| Title | Cancer incidence in a chlorochemical plant in Isère, France: an occupational cohort study, 1979-2002 |
| Authors | Bonneterre, V; Mathern, G; Pelen, O; Balthazard, AL; Delafosse, P; Mitton, N; Colonna, M |
| Journal | American Journal of Industrial Medicine |
| Volume | 55 |
| Issue | 9 |
| Page Numbers | 756-767 |
| Abstract | <strong>BACKGROUND: </strong>A major French chlorine chemical plant (chlor-alkali process with diaphragm cell and manufacturing of organochlorine chemicals) has used or produced known or suspected carcinogenic compounds.<br /><br /><strong>METHODS: </strong>A cohort study, based on the plant occupational health service and the regional cancer registry, analyzed the standardized incidence ratios of malignant tumors for the period 1979-2002. Individual exposures were estimated from workers' occupational histories in a dual division of jobs into 9 sectors and 115 workshops with known exposures.<br /><br /><strong>RESULTS: </strong>Men (2,742) were followed, corresponding to 52,794 person-years. Primary tumors (304) were observed for 290 expected cases, a non-significant 5% excess. A significant excess was found of pleural mesothelioma and bladder cancer in employees hired before 1964.<br /><br /><strong>CONCLUSION: </strong>Excesses of mesothelioma and bladder cancer were found, whereas there was no excess of hematopoietic cancers despite high benzene and dioxin exposures. Surprisingly, mesothelioma cases did not include workers who were the most exposed to asbestos. |
| Doi | 10.1002/ajim.22069 |
| Pmid | 22692930 |
| Wosid | WOS:000307384700002 |
| Url | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84864984404&doi=10.1002%2fajim.22069&partnerID=40&md5=f2de3a1836a1eb18e14c18f3b813b038 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | occupational exposure (MeSH); epidemiology (MeSH); cohort studies (MeSH); cancer (MeSH?=?neoplasm); chemical industry (MeSH); occupational health (MeSH); occupational diseases (MeSH) |