The role of fiber durability/biopersistence of silica-based synthetic vitreous fibers and their influence on toxicology
Maxim, LD; Hadley, JG; Potter, RM; Niebo, R
HERO ID
1799703
Reference Type
Journal Article
Subtype
Review
Year
2006
Language
English
PMID
| HERO ID | 1799703 |
|---|---|
| Material Type | Review |
| In Press | No |
| Year | 2006 |
| Title | The role of fiber durability/biopersistence of silica-based synthetic vitreous fibers and their influence on toxicology |
| Authors | Maxim, LD; Hadley, JG; Potter, RM; Niebo, R |
| Journal | Regulatory Toxicology and Pharmacology |
| Volume | 46 |
| Issue | 1 |
| Page Numbers | 42-62 |
| Abstract | This work summarizes what is known about the role of fiber durability/biopersistence of silica-based synthetic vitreous fibers (SVFs) and their influence on toxicology. The article describes the key processes leading from exposure to biological effect, including exposure, pulmonary deposition, clearance by various mechanisms, accumulation in the lung, and finally possible biological effects. The dose-dimension-durability paradigm is used to explain the key determinants of SVF toxicology. In particular, the key role played by the durability/biopersistence of long (>20microm) fibers is highlighted. Relevant literature on the prediction of in-vitro dissolution rates from chemical composition is summarized. Data from in-vitro and in-vivo durability/biopersistence tests show that these measures are highly correlated for long fibers. Both durability and biopersistence are correlated with the outcome of chronic inhalation bioassays. A schematic approach is presented for the design and testing of new SVFs with lower biopersistence. |
| Doi | 10.1016/j.yrtph.2006.05.003 |
| Pmid | 16837114 |
| Wosid | WOS:000240703200005 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | synthetic vitreous fibers; durability; biopersistence; toxicology |