Severe gastroesophageal reflux is associated with reduced carbon monoxide diffusing capacity
Schachter, LM; Dixon, J; Pierce, RJ; O'Brien, P
| HERO ID | 186707 |
|---|---|
| In Press | No |
| Year | 2003 |
| Title | Severe gastroesophageal reflux is associated with reduced carbon monoxide diffusing capacity |
| Authors | Schachter, LM; Dixon, J; Pierce, RJ; O'Brien, P |
| Journal | Chest |
| Volume | 123 |
| Issue | 6 |
| Page Numbers | 1932-1938 |
| Abstract | Objective. To assess whether severe gastroesophageal reflux (GER) is associated with abnormalities in lung function including measures of lung volume and gas diffusion. <br> <br>Methods: Data from 147 patients with obesity (body mass index [BMI] range, 31.7 to 70 kg/m(2)) who presented for obesity surgery was analyzed retrospectively. A questionnaire was completed preoperatively that included a history of GER, frequency and severity of symptoms, investigations, and medications used. A history of lung disease, sleep-disordered breathing, and smoking also was obtained. A physician who was blinded to lung function graded GER severity prospectively by the results of pH monitoring and/or gastroscopy, and medication use. Spirometry, lung volumes, and gas transfer were measured preoperatively. <br> <br>Results: Patients with severe GER had reduced levels of the diffusing capacity of the lung for carbon monoxide (DLCO) [21.1 mL/min/mm Hg; 95% confidence interval (CI), 18.9 to 23.2], as measured by CO transfer, compared with those patients without GER (26.3 mL/min/mm Hg; 95% CI, 24.4 to 28.2; p = 0.001). This remained significant after adjusting for age, gender, BMI, and smoking history. Gas transfer corrected for lung volume also was reduced in the group with severe GER (4.6 mL/min/mm Hg per L; 95% CI, 4.3 to 4.9) compared to the group without GER (5.3 mL/min/mm Hg per L; 95% CI, 5.1 to 5.5; p = 0.001). There was no significant difference in other measures of lung function. <br> <br>Conclusions: Severe GER is associated with an impairment of gas exchange. This may be due to microaspiration of gastric acid or fluid into the airways. |
| Doi | 10.1378/chest.123.6.1932 |
| Pmid | 12796170 |
| Wosid | WOS:000183519000026 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | N1-JunSN-0012-3692 (Print)N1-Severe gastroesophageal reflux is associated with reduced carbon monoxide diffusing capacityN1-12796170N1-Schachter, Linda MDixon, JohnPierce, Robert JO'Brien, PaulUnited StatesChestChest. 2003 Jun;123(6):1932-8.N1-engKW-AdultCarbon Monoxide/*metabolismFemaleGastroesophageal Reflux/etiology/*physiopathologyHumansMaleObesity/physiopathologyPulmonary Diffusing Capacity/*physiologyPulmonary Gas Exchange/physiologyRespiratory Function TestsRetrospective StudiesN2-OBJECTIVE: To assess whether severe gastroesophageal reflux (GER) is associated with abnormalities in lung function including measures of lung volume and gas diffusion. METHODS: Data from 147 patients with obesity (body mass index [BMI] range, 31.7 to 70 kg/m(2)) who presented for obesity surgery was analyzed retrospectively. A questionnaire was completed preoperatively that included a history of GER, frequency and severity of symptoms, investigations, and medications used. A history of lung disease, sleep-disordered breathing, and smoking also was obtained. A physician who was blinded to lung function graded GER severity prospectively by the results of pH monitoring and/or gastroscopy, and medication use. Spirometry, lung volumes, and gas transfer were measured preoperatively. RESULTS: Patients with severe GER had reduced levels of the diffusing capacity of the lung for carbon monoxide (DLCO) [21.1 mL/min/mm Hg; 95% confidence interval (CI), 18.9 to 23.2], as measured by CO transfer, compared with those patients without GER (26.3 mL/min/mm Hg; 95% CI, 24.4 to 28.2; p = 0.001). This remained significant after adjusting for age, gender, BMI, and smoking history. Gas transfer corrected for lung volume also was reduced in the group with severe GER (4.6 mL/min/mm Hg per L; 95% CI, 4.3 to 4.9) compared to the group without GER (5.3 mL/min/mm Hg per L; 95% CI, 5.1 to 5.5; p = 0.001). There was no significant difference in other measures of lung function. CONCLUSIONS: Severe GER is associated with an impairment of gas exchange. This may be due to microaspiration of gastric acid or fluid into the airways.AD-Institute for Breathing and Sleep, Austin and Repatriation Medical Centre, Heidelberg, VIC, Australia. lindams@bigpond.comUR-http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12796170ID-12 |
| Is Public | Yes |
| Language Text | English |
| Keyword | diffusing capacity; gastroesophageal reflux; lung function |
| Is Qa | No |