Chronic Inhalation of Asbestos and Cigarette Smoke by Hamsters
Wehner, AP; Busch, RH; Olson, RJ; Craig, DK
| HERO ID | 1920183 |
|---|---|
| In Press | No |
| Year | 1975 |
| Title | Chronic Inhalation of Asbestos and Cigarette Smoke by Hamsters |
| Authors | Wehner, AP; Busch, RH; Olson, RJ; Craig, DK |
| Journal | Environmental Research |
| Volume | 10 |
| Issue | 3 |
| Page Numbers | 368-383 |
| Abstract | Male hamsters received chronic exposures to a respirable aerosol of Canadian chrysotile asbestos 7 hours per day, 5 days per week. Half of the animals were also exposed for 10 minutes to cigarette smoke three times per day, 5 days per week, for the duration of their life span. The other half of the animals received sham smoke exposures. Another group of hamsters served as controls. Half of the controls received smoke exposures, the other half received sham exposures. Asbestos exposure resulted in earlier and more severe lung lesions than in identical groups of concurrent experiments, which had received life span exposures to aerosols of nickel-oxide and cobalt-oxide, or which were treated with diethylnitrosamine. Asbestosis developed in all animals and forced discontinuation of the asbestos exposures after 11 months. Of 12 lung adenomas found in 510 hamsters, ten occurred among the 102 animals of the asbestos exposed groups, indicating an early neoplastic response. However, perhaps on account of their significantly shorter life span due to asbestosis, the incidence of laryngeal lesions and of malignant tumors was significantly lower in the asbestos plus smoke exposed group than in the control group having received smoke exposures. Neither a carcinogenic effect of asbestos nor a cocarcinogenic effect of cigarette smoke was observed. Cigarette smoke inhalation resulted in significantly lower mean body weights of the smoke exposed groups. |
| Pmid | 1213018 |
| Wosid | WOS:A1975BE07600004 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | Aerosols; Index Medicus; Cricetinae; Body Weight; Aerosols -- adverse effects; Laryngeal Diseases -- chemically induced; Lung -- pathology; Lung Diseases -- chemically induced; Inflammation -- chemically induced; Macrophages -- pathology; Lung Diseases -- pathology; Animals; Lung Neoplasms -- chemically induced; Chronic Disease; Asbestosis -- mortality; Smoking -- mortality; Asbestosis -- pathology; Smoking -- pathology; Smoking -- complications; Asbestosis -- complications |