Butylated hydroxytoluene exposure is necessary to induce lung tumors in BALB mice treated with 3-methylcholanthrene
Malkinson, AM; Koski, KM; Evans, WA; Festing, MF
HERO ID
1936454
Reference Type
Journal Article
Year
1997
Language
English
PMID
| HERO ID | 1936454 |
|---|---|
| In Press | No |
| Year | 1997 |
| Title | Butylated hydroxytoluene exposure is necessary to induce lung tumors in BALB mice treated with 3-methylcholanthrene |
| Authors | Malkinson, AM; Koski, KM; Evans, WA; Festing, MF |
| Journal | Cancer Research |
| Volume | 57 |
| Issue | 14 |
| Page Numbers | 2832-2834 |
| Abstract | Chronic butylated hydroxytoluene (BHT) treatment after a single administration of a carcinogen increases lung tumor multiplicity in some inbred strains of mice. We report that BALB/cOla and BALB/cByJ mice given a low dose (10 microg/g of body weight) of 3-methylcholanthrene (MCA) develop no lung tumors unless this is followed by chronic BHT exposure. Slightly higher MCA doses (15 and 25 microg/g) induce low lung tumor multiplicities (0.6 and 1.9 tumors/mouse, respectively) that are increased 12-26-fold by chronic BHT administration. This low-dose MCA/BHT model in BALB mice will facilitate the identification of genes regulating susceptibility to lung tumor promotion and pulmonary chemopreventative agents that act at a postinitiation site. |
| Pmid | 9230183 |
| Wosid | WOS:A1997XL16200004 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Scopus URL: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0030745488&partnerID=40&md5=c5d3c62244c91a99aa3c6c1858666a56 |
| Is Public | Yes |
| Language Text | English |