Sub-acute, moderate-dose, but not short-term, low-dose dietary pre-exposure of mice to perfluorooctanoate aggravates concanavalin A-induced hepatitis
Qazi, MR; Hassan, M; Nelson, BD; Depierre, JW; Abedi-Valugerdi, M
HERO ID
1937224
Reference Type
Journal Article
Year
2013
Language
English
PMID
| HERO ID | 1937224 |
|---|---|
| In Press | No |
| Year | 2013 |
| Title | Sub-acute, moderate-dose, but not short-term, low-dose dietary pre-exposure of mice to perfluorooctanoate aggravates concanavalin A-induced hepatitis |
| Authors | Qazi, MR; Hassan, M; Nelson, BD; Depierre, JW; Abedi-Valugerdi, M |
| Journal | Toxicology Letters |
| Volume | 219 |
| Issue | 1 |
| Page Numbers | 1-7 |
| Abstract | Exposure of mice to perfluorooctanoate (PFOA) evokes pronounced hepatomegaly along with significant alterations in both the histological structure and immune status of the liver. The present study was designed to evaluate the effects of this perfluorochemical on immune-mediated liver damage. In this connection, the influence of both sub-acute (10 days), moderate-dose (0.002% w/w=3±0.7mg/kg body weight/day) and short-term (28 days), low-dose (0.00005% w/w=70±2μg/kg body weight/day) dietary pretreatment with PFOA on the development of concanavalin A (Con A)-induced liver damage in mice was examined. With sub-acute, moderate, but not short-term, low-dose exposure, PFOA aggravated the acute liver damage caused by Con A, i.e., elevated serum levels of transaminases and led to more pronounced damage of hepatic tissue. This aggravation was associated with significantly enhanced hepatic level of interleukin-6 (IL-6), but unaltered hepatic levels of tumor necrosis factor-alpha (TNF-α), interferon-gamma (IFN-γ) and interleukin-4 (IL-4). Moreover, hepatic DNA fragmentation was not changed by sub-acute exposure to the moderate-dose. Our findings imply that exposure to PFOA may sensitize hepatic parenchymal cells to other toxicants that activate the hepatic immune system and thereby aggravate liver injury during acute inflammation. |
| Doi | 10.1016/j.toxlet.2013.02.017 |
| Pmid | 23458897 |
| Wosid | WOS:000317348100001 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Potential Matches To This Reference: 1937224 4694028 Potential Matches To This Reference: 1937224 4694028 |
| Is Public | Yes |
| Language Text | English |