Ammonium perfluorooctanoate substantially alters phenotype and cytokine secretion of human monocyte-derived dendritic cells in vitro
Ahuja, V; Eisenblätter, M; Ignatius, R; Stahlmann, R
HERO ID
1937253
Reference Type
Journal Article
Year
2009
Language
English
PMID
| HERO ID | 1937253 |
|---|---|
| In Press | No |
| Year | 2009 |
| Title | Ammonium perfluorooctanoate substantially alters phenotype and cytokine secretion of human monocyte-derived dendritic cells in vitro |
| Authors | Ahuja, V; Eisenblätter, M; Ignatius, R; Stahlmann, R |
| Journal | Immunopharmacology and Immunotoxicology |
| Volume | 31 |
| Issue | 4 |
| Page Numbers | 641-646 |
| Abstract | Perfluoroalkyl carboxylic acids (PFCA) are commercially used for their surfactant properties combined with chemical and thermal stability. Differentiation of peripheral monocytes to immature dendritic cells (DCs) in the presence of the PFCA, ammonium perfluorooctanoate (APFO, 200 microM) led to a considerably increased expression of CD86 and HLA-DR on immature DCs. However, these phenotypic changes were not reflected by an increased T cell-stimulatory capacity of the cells. Notably, activated, fully mature APFO-treated DCs secreted significantly less IL-12 and IL-10 than control cells. Thus, APFO at non-cytotoxic concentration affects the phenotype and cytokine secretion of human DCs. |
| Doi | 10.3109/08923970902947317 |
| Pmid | 19874235 |
| Wosid | WOS:000275067400020 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |