COHb% as a marker of cardiovascular risk in never smokers: results from a population-based cohort study
Hedblad, B; Engström, G; Janzon, E; Berglund, G; Janzon, L
HERO ID
199512
Reference Type
Journal Article
Year
2006
Language
English
PMID
| HERO ID | 199512 |
|---|---|
| In Press | No |
| Year | 2006 |
| Title | COHb% as a marker of cardiovascular risk in never smokers: results from a population-based cohort study |
| Authors | Hedblad, B; Engström, G; Janzon, E; Berglund, G; Janzon, L |
| Journal | Scandinavian Journal of Public Health |
| Volume | 34 |
| Issue | 6 |
| Page Numbers | 609-615 |
| Abstract | AIM: Carbon monoxide (CO) in blood as assessed by the COHb% is a marker of the cardiovascular (CV) risk in smokers. Non-smokers exposed to tobacco smoke similarly inhale and absorb CO. The objective in this population-based cohort study has been to describe inter-individual differences in COHb% in never smokers and to estimate the associated cardiovascular risk. METHODS: Of the 8,333 men, aged 34-49 years, from the city of Malmö, Sweden, 4,111 were smokers, 1,229 ex-smokers, and 2,893 were never smokers. Incidence of CV disease was monitored over 19 years of follow up. RESULTS: COHb% in never smokers ranged from 0.13% to 5.47%. Never smokers with COHb% in the top quartile (above 0.67%) had a significantly higher incidence of cardiac events and deaths; relative risk 3.7 (95% CI 2.0-7.0) and 2.2 (1.4-3.5), respectively, compared with those with COHb% in the lowest quartile (below 0.50%). This risk remained after adjustment for confounding factors. CONCLUSION: COHb% varied widely between never-smoking men in this urban population. Incidence of CV disease and death in non-smokers was related to COHb%. It is suggested that measurement of COHb% could be part of the risk assessment in non-smoking patients considered at risk of cardiac disease. In random samples from the general population COHb% could be used to assess the size of the population exposed to second-hand smoke. |
| Doi | 10.1080/14034940600590523 |
| Pmid | 17132594 |
| Wosid | WOS:000242346600008 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | Carbon monoxide; Epidemiology; Myocardial infarction; Passive smoking |
| Is Qa | No |