Postnatal exposure to chlorinated dioxins and related chemicals on lymphocyte subsets in Japanese breast-fed infants
Nagayama, J; Tsuji, H; Iida, T; Hirakawa, H; Matsueda, T; Okamura, K; Hasegawa, M; Sato, K; Ma, HY; Yanagawa, T; Igarashi, H; Fukushige, J; Watanabe, T
HERO ID
199664
Reference Type
Journal Article
Year
1998
Language
English
PMID
| HERO ID | 199664 |
|---|---|
| In Press | No |
| Year | 1998 |
| Title | Postnatal exposure to chlorinated dioxins and related chemicals on lymphocyte subsets in Japanese breast-fed infants |
| Authors | Nagayama, J; Tsuji, H; Iida, T; Hirakawa, H; Matsueda, T; Okamura, K; Hasegawa, M; Sato, K; Ma, HY; Yanagawa, T; Igarashi, H; Fukushige, J; Watanabe, T |
| Journal | Chemosphere |
| Volume | 37 |
| Issue | 9-12 |
| Page Numbers | 1781-1787 |
| Abstract | Effects of postnatal exposure to polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated diberuofurans (PCDFs) and coplanar polychlorinated biphenyls (Co-PCBs) on lymphocyte subpopulations were investigated in the peripheral blood of 36 breast-fed Japanese babies. As a result, estimated total intakes of these chemicals in toxic equivalent quantity (TEQ) converted into 2,3,7,8- tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD) equivalents from the breast milk positively and negatively correlated with the respective percentages of CD4+ and CDS+ lymphocytes in the blood of breast-fed babies. Consequently, the ratios of CD4+ to CDS+ T cells showed significant increasing tendency with the estimated total TEQ intakes. Therefore, our study suggests that exposure to background levels of the highly toxic organochlorine compounds through the breast milk influences the human neonatal immune system. |
| Doi | 10.1016/S0045-6535(98)00243-4 |
| Pmid | 9828306 |
| Wosid | WOS:000076618700014 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | Lactational exposure; Polychlorinated dibenzo-p-dioxins; Polychlorinated dibenzofurans; Coplanar PCBs; Lymphocyte subsets; Japanese infants |
| Is Qa | No |