What is required for the validation of in vitro assays for predicting contaminant relative bioavailability? Considerations and criteria
Juhasz, AL; Basta, NT; Smith, E
| HERO ID | 2064145 |
|---|---|
| In Press | No |
| Year | 2013 |
| Title | What is required for the validation of in vitro assays for predicting contaminant relative bioavailability? Considerations and criteria |
| Authors | Juhasz, AL; Basta, NT; Smith, E |
| Journal | Environmental Pollution |
| Volume | 180 |
| Page Numbers | 372-375 |
| Abstract | A number of studies have shown the potential of in vitro assays to predict contaminant in vivo relative bioavailability in order to refine human health exposure assessment. Although the term ‘validated’ has been used to describe the goodness of fit between in vivo and in vitro observations, its misuse has arisen from semantic considerations in addition to the lack of defined criteria for establishing performance validation. While several internal validation methods may be utilised, performance validation should preferably focus on assessing the agreement of model predictions with a set of data which are independent of those used to construct the model. In order to achieve robust validated predictive models, a number of parameters (e.g. size of data set, source of independent soils, contaminant concentration range, animal model, relative bioavailability endpoint) need to be considered in addition to defined criteria for establishing performance validation which are currently lacking. |
| Doi | 10.1016/j.envpol.2013.05.008 |
| Pmid | 23725856 |
| Wosid | WOS:000322425300048 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | Bioaccessibility; Bioavailability; Correlation; Human health risk assessment; Validation |